Systemic hormone replacement therapy in menopausal women may increase the risk of depression. Especially in patients under 50 years of age. A Danish study shows this.
Systemic hormone replacement therapy may be associated with a greater risk of depression before and during menopause. This is shown by a study published in the journal JAMA Open Network. The risk is particularly high in the first years after starting treatment.
During menopause, estrogen and progesterone levels drop. 60 to 70 percent of women then suffer from menopausal symptoms such as mood swings and hot flashes. This is to prevent the administration of hormones.
The researchers evaluated the formulas for hormonal preparations
The nationwide study included all women in Denmark aged 45 from January 1, 1995 to December 31, 2017. They had not had their ovaries removed, had breast cancer, or cancer of the reproductive organs. They were observed until December 31, 2018.
Researchers from Bispebjerg and Frederiksberg Hospitals in Frederiksberg evaluated prescriptions for different types of hormone replacement therapy filled between 1995 and 2017. The method of administration was divided into systemic (oral or transdermal) and local (intravaginal or intrauterine).
Hormone replacement therapy may increase the risk of depression
The results showed that from age 45 to an average age of 56, 189,821 women received systemic or topical hormone replacement therapy (23 percent), and 13,069 were diagnosed with depression (1.6 percent).
Systemic hormone replacement therapy was started primarily before the age of 50 and was associated with a higher risk of later depression, especially in women aged 45 to 50 years. In addition, the risk was particularly increased one year after starting treatment with both estrogen alone and estrogen plus progestogen.
Topical hormone therapy reduced the risk of depression from age 54
Topically administered hormone replacement therapy was not associated with an increased risk of depression in women under 45 years of age. It was even associated with a reduced risk of depression when it started after age 54.