High fat diet leads to more pain – healing practice

High-fat diets appear to increase sensitivity to pain

Specific fatty acidswhich is multiplied through a high fat diet is included according to a recent study Neurons to bind, thereby to influence more sensitive to pain react or even pain without cause could feel

researchers from University of Texas at Dallas (USA) found that the fatty acid so-called palmitic acid (palmitic acid) binds to a specific receptor on nerve cells. According to the results of a study recently presented in the renowned journal Scientific Reports, this process mimics a Nerve cell damage after and leads to inflammation.

Increased pain due to saturated fatty acids

Research suggests that a high-fat diet sa increased sensitivity to pain is connected. The pain sensations that arise in this way appear simultaneously independently any injury or pre-existing conditions.

Change after just eight weeks

The research group discovered in mice that for eight weeks were fed a high-fat diet. The control group was fed a normal diet instead. The high-fat diet was designed to No for development overweight or high blood sugar guided.

Same changes as chronic pain

A comparison of these two groups showed that mice fed a high-fat diet developed the so-calledhyperalgesic primer” developed. It refers to neurological changes on nerve cells, which also occurs during the transition from acute to chronic pain be tracked.

As a result of the change, the mice developed a Allodynia – a condition where pain is triggered by stimuli that are not normally associated with pain, such as light touches.

“This study shows that you can feel pain without having diabetes or any other pathology or injury.”confirmed by the corresponding study author Dr. Michael Burton.

A Western diet high in saturated fat

According to him, a short-term high-fat diet is enough to develop these symptoms. He also points out that such a diet in the US enlarged Yippee.

The Western diet is generally high in saturated fat, which has been shown to promote diseases such as obesity and diabetes and related diseases. According to the researchers, the discovered mechanism may partially explain why the consumption of saturated fat systemic inflammation can cause.

Neuronal injury by palmitic acid

According to the working group, it will mainly be about changes induced by palmitic acid. This is about the most common saturated fatty acids in food.

“Dietary metabolites cause inflammation before pathology develops”he explained Dr. Burton. The decisive factor here is the diet itself neuronal injury mediated.

In a follow-up study, the team now wants to investigate why neurons change when palmitic acid binds. “If we can find a way to prevent the transition from acute to chronic pain, that could do a lot of good.”, summarizes the author of the study. (vb)

Author and source information

This text meets the requirements of the medical literature, medical guidelines and current studies and has been reviewed by health professionals.


Postgraduate editor (ZF) Volker Blašek


  • University of Texas at Dallas: UTD researchers find high-fat diet can induce pain sensitivity (veröffentlicht: 11/11/2022), news.utdallas.edu
  • Jessica A. Tierney, Calvin D. Uong, Melissa E. Lenert, et al.: A high-fat diet causes mechanical allodynia without injury or diabetic pathology; in: Scientific Reports (2022), nature.com

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a doctor’s visit.

Leave a Comment