Protection against Alzheimer’s disease by catechins and resveratrol
Green tea and Red wine contain connections that apparently Alzheimer’s counteracts damage to nerve cells due to formation Beta-amyloid plaques reduce. This could also open up new approaches to preventing and treating Alzheimer’s disease.
In a new study by experts from Tufts University 21 different drugs, dietary supplements and health foods with potential neuroprotective properties were tested in the model. Alzheimer’s disease caused by herpes viruses researched. The results are published in the journal Free Radical Biology and Medicine.
Alzheimer’s disease caused by the herpes virus
At the beginning of this year, scientists from Tufts University managed to demonstrate on a 3D model of living human brain cells that Herpes virus to Plaque formation in the brain findings associated with Alzheimer’s disease.
The team is currently working to identify ways to achieve this Slow the progression of Alzheimer’s disease be able. To do this, they investigated the effect in the laboratory 21 connections on the growth of amyloid beta plaques that form in the brain in Alzheimer’s disease.
Antiviral Agents to Fight Alzheimer’s Disease
Among the 21 compounds studied were some that showed beneficial effects in a herpesvirus-induced model of Alzheimer’s disease. In the first screening, five were initially identified with really strong prevention of amyloid beta plaques are linked, reports the study’s author Dana Cairns.
Next to catechins and resveratrol it was this curcuminwhich is found in turmeric, a diabetes medicine metformin and active ingredient Citicoline.
Strong efficacy and almost no side effects
“We hoped to find compounds that were harmless and had some level of efficacy. We were lucky that some of them showed quite strong potency“, he explained Cairns in a Tufts University press release.
These were molecules in green tea leaves called catechins and Resveratrol which is found, for example, in red wine and other foods.
With these compounds, virtually no plaques were visible on the model after about a week, the study author points out. In addition, the reduction of plaque formation by catechins and resveratrol with little or no side effects was connected.
However, it should be noted that even if the effects of the compounds were observed in the laboratory, it does not necessarily correspond to the effects that ultimately occur in humans, Cairns said.
For example, there are connections that are not able, so-called blood-brain barrier overcome and other connections have low bioavailabilitywhich is why they cannot be easily absorbed into the body or bloodstream.
Dietary intake of resveratrol and catechins
One of the advantages of resveratrol and catechins is that they show some efficacy and can be easily obtained through supplements or regular diet.
“Examples of natural sources of resveratrol include red wine, certain fruits such as grapes, blueberries and cranberries, peanuts, pistachios and cocoa.“reports the expert.
Although it is helped by resveratrol and catechins prevent neurodegenerationbut be one medical consultation connected before it amplifies independently changes in his diet does
According to Cairns, future studies should also investigate how the positive properties of resveratrol and catechins can be best used and improved e.g. Optimized bioavailability or that Facilitated penetration through the blood-brain barrier is happening (as)
Author and source information
This text meets the requirements of the medical literature, medical guidelines and current studies and has been reviewed by health professionals.
- Isabella A. Silveira, Adam S. Mullis, Dana M. Cairns, Anna Shevzov-Zebrun, Jordyn Whalen, et al.: Screening of Neuroprotective Compounds in Herpes-Induced Cell Models of Alzheimer’s Disease and 3D Tissue Models; in: Free Radical Biology and Medicine (veröffentlicht Volume 186, June 2022, pages 76-92), Free Radical Biology and Medicine
- Tufts University: Green tea and resveratrol reduce Alzheimer’s plaques in lab tests (veröffentlicht 01.11.2022), Tufts University
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a doctor’s visit.